Employing solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our research passions incorporate:
Our team scientific tests bacterial cell division and it is aiming to constitute a ‘base up biology’ in synthetic cells that may autonomously divide. Our main desire lies in cell division, chromatin structure, and spatial control.
Back again in 1991, Sumio Iijima with the NEC Company experienced reported the synthesis of carbon nanotubes. Band structure calculations recommended that these nanotubes could exhibit metallic band conduction. This could be a major benefit above the conducting polymers we had explored, which had been, actually, disordered semiconductors providing merely variable-variety hopping conductivity.
2007, 1st serious-time detection of strand exchange in homologous recombination by RecA; discovery of a small persistence length of ends of microtubules; and fixed the mechanism of biosensing with carbon nanotubes
2015, discovery that condensin is usually a hugely versatile protein structure; and to start with detection of DNA knots employing nanopores
Example (three) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, the rim from the pore is highlighted in pink, plus a 3D rendering in the movement on the DNA rod is displayed.
Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with study from DNA supercoiling studies of nucleosomes and DNA restore proteins to DNA translocation as a result of nanopores. Not long ago his investigation has focused on researching cell division ceesdekker with bacteria on chip, though his best curiosity is in the way of acknowledging synthetic cells.
2000, discovery that nanotubes can have incredible huge present-day densities; resolved the controversial situation of Digital transport by means of DNA molecules by measurements of insulating habits at The one molecule level; and demonstration of the AFM system for single-molecule manipulation of nanotubes
‘You shouldn't just take into consideration the queries of tomorrow, but also evaluate the issues with the day following tomorrow’
Very cool, but that wasn’t really where my desire lay. I needed to pioneer And that i had the feeling which was no longer possible, as the most appealing elementary insights had currently been uncovered. But my field experienced formulated a lot of fascinating new resources to measure unique molecules. I made a decision that I wanted to utilize this to biology, to take a look at it from a physical standpoint.’
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2004, discovery of recent physics in translocation of DNA by way of nanopores; very first experimental study of ions conduction in nanofluidic channels; initially electrochemistry with personal single-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; initial electrical docking of microtubules on kinesin-coated nanostructures; to start with biophysics characterization on the mechanical properties of double-stranded RNA; and initially single-molecule analyze of DNA translocation by a restriction-modification enzyme.